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KMID : 1159320220240010043
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Korean Journal of Vision Science
2022 Volume.24 No. 1 p.43 ~ p.50
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Preparation and Characterization of Biocompatible and High Functional Hydrogel Lenses Containing Collagen Material
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Heo Ji-Won
Shin Su-Mi
Kim Dal-Won
Sung A-Young
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Abstract
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Purpose : In this study, a high-functional ophthalmic polymer was prepared using various additives based on PDMS, and then, the prepared lens surface was coated with collagen with excellent biocompatibility and wettability to compare and analyze the physical properties.
Methods : Polydimethylsiloxane (PDMS) and hydrophilic monomers N,N-dimethylacrylamide (DMA) and 2-Hydroxyethyl methacrylate (HEMA) were used as main materials for lens manufacturing. Ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent and Azobisisobutyronitrile (AIBN) as a thermal initiator were used. In addition, 1,3-Bis (3-aminopropyl)tetramethyldisiloxane (TMDS), Polyvinylpyrrolidone (PVP), 2-(Trifluoromethyl) styrene and collagen were used as functional additives. Light transmittance, refractive index, water content, oxygen transmittance, and tensile strength were respectively measured to evaluate the physical properties of the manufactured lens, and wettability was evaluated by measuring the contact angle.
Results : The addition of TMDS showed the oxygen transmittance of the lens as about 28 to 45×10?¹¹(cm²/sec)(mlO²/ml×mmHg) depending on the addition ratio. In addition, the addition of PVP and 2-(Trifluoromethyl)styrene showed the wettability and tensile strength of the lens as about 56~46° and about 0.11~0.17 kgf/mm² depending on the addition ratio, respectively. It was found that the functionality of the manufactured lens was improved by using various additives, and in particular, the use of the collagen additive, the contact angle of the surface of the hydrogel was greatly reduced to have excellent wettability.
Conclusion : Therefore, TMDS, PVP and 2-(Trifluoromethyl)styrene are effective in improving the functionality of silicone hydrogel lenses, and the use of collagen as an additive improves the wettability of lenses.
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KEYWORD
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Collagen, Hydrogel lens, PDMS, Wettability
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